Polydatin: a new therapeutic agent against multiorgan dysfunction

Cotinine: a potential new therapeutic agent against Alzheimer's disease.

Tobacco smoking has been correlated with a lower incidence of Alzheimer's disease (AD). This negative correlation has been attributed to nicotine's properties. However, the undesired side-effects of nicotine and the absence of clear evidence of positive effects of this drug on the cognitive abilities of AD patients have decreased the enthusiasm for its therapeutic use. In this review, we discus...

Terramycin as a Therapeutic Agent against Mumps

Polydatin Protecting Kidneys against Hemorrhagic Shock-Induced Mitochondrial Dysfunction via SIRT1 Activation and p53 Deacetylation

OBJECTIVES To ascertain if mitochondrial dysfunction (MD) of kidney cells is present in severe hemorrhagic shock and to investigate whether polydatin (PD) can attenuate MD and its protective mechanisms. RESEARCH DESIGN AND METHODS Renal tubular epithelial cells (RTECs) from rat kidneys experiencing HS and a cell line (HK-2) under hypoxia/reoxygenation (H/R) treatment were used. Morphology and...

Patterns of multiorgan dysfunction after pediatric drowning.

AIMS To evaluate patterns of multiorgan dysfunction and neurologic outcome in children with respiratory and cardiac arrest after drowning. METHODS Single center retrospective chart review of children aged 0-21 years admitted between January 2001 and January 2012 to the pediatric intensive care unit at Children's Hospital of Pittsburgh with a diagnosis of drowning/submersion/immersion. Organ d...

multiorgan dysfunction: a rare complication of typhoid fever

typhoid fever is a common infection in children in developing countries. typhoid fever is a systemic illness which affects many organs. isolated hepatitis, thrombocytopenia and acute renal failure complicating typhoid fever are well known. the potential of multiorgan involvement in typhoid fever - on rare occasions - may occur simultaneously in the same patient.